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June 02, 2000 3:25 p.m.
Teva Pharmaceutical Industries Ltd. Announces Copaxone® Recommended for Approval in the U.K. a Major Step Towards the Approval in the E.U.

Jerusalem, Israel, June 2, 2000 - Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA) today announced that Copaxone® (glatiramer acetate for injection) has been recommended for approval for the treatment of relapsing-remitting multiple sclerosis (RR MS) by the Licensing Authority in the U.K. It is anticipated that a marketing authorization will be issued shortly.

"We are extremely pleased with the news", said Mr. Eli Hurvitz, Teva's President and CEO, "Teva has been confident all along that the growing body of scientific and clinical evidence regarding Copaxone® will satisfy the stringent requirements of the U.K. Teva has worked closely together with the U.K. authorities to achieve this goal".

Following the approval in the U.K., Teva will initiate the European mutual recognition procedure to make Copaxone® available in the remainder of the European Union and will ask the U.K. to act as the reference member state. The successful completion of this procedure will enable the launch of Copaxone® in the E.U. during the first half of 2001.

"This recommendation for approval means that neurologists will shortly have a much-needed option to offer people with relapsing-remitting multiple sclerosis", said Prof. Lance Blumhardt of Queen's Medical Centre, U.K., "Glatiramer acetate, with its proven clinical benefits and excellent patient tolerability, represents a significant addition to treatment options for people with RRMS. Glatiramer acetate is also the drug of choice for people who fail with beta interferons or who cannot tolerate their side-effects".

Copaxone® represents a new class of therapy for MS, an MS specific immunomodulator. Copaxone® is the first and only non-interferon agent proven to reduce the frequency of relapses in patients with relapsing-remitting MS.

Similar to the U.S., there are 150,000 relapsing-remitting patients in the E.U. Importantly, the untreated MS population in Europe is at least twice as large as that of the U.S. As a widely accepted first-line therapy and the drug of choice for patients who do not benefit or cannot tolerate beta-interferon, Copaxone® is poised to gain its share rapidly.

Copaxone® has been approved in the U.S. since December 1996 and is the fastest growing MS therapy and the second most prescribed MS drug in the U.S. This growth is fueled by continued evidence emerging from on-going basic research and clinical work done with Copaxone®.

Copaxone® is currently approved in 18 countries including the U.S, Canada, Israel, Switzerland and Australia. Since the beginning of this year, Copaxone® has been approved in Turkey, the Czech Republic, Slovakia and Poland.

"The recommendation of approval by the U.K. Licensing Authority represents a major milestone for Teva and for Israeli research" further commented Mr. Eli Hurvitz. "It means that Copaxone® will become Teva's first globally marketed innovative pharmaceutical product. Copaxone® will be the first such product to emerge from Teva's close relationship with the world renowned academic research institutes in Israel". Copaxone® was discovered at the Weizmann Institute of Science in Israel.

Teva continues to invest heavily in further developing Copaxone® for the treatment of MS. The company is actively developing both an Oral formulation of Copaxone® and conducting a major clinical trial investigating the safety and efficacy of Copaxone® for the primary progressive stage of the disease.

Teva Pharmaceutical Industries Ltd., headquartered in Israel, is among the top 50 pharmaceutical companies and among the largest generic pharmaceutical companies in the world. Over 80% of its sales are outside Israel, mainly in the United States and Europe. The Company develops, manufactures and markets generic and branded pharmaceuticals and active pharmaceutical ingredients.






Safe Harbor Statement under the U. S. Private Securities Litigation Reform Act of 1995: This release contains forward-looking statements, which express the current beliefs and expectations of management. Such statements are based on current expectations and involve a number of known and unknown risks and uncertainties that could cause Teva's future results, performance or achievements to differ significantly from the results, performance or achievements expressed or implied by such forward-looking statements. Important factors that could cause or contribute to such differences include Teva's ability to successfully develop and commercialize additional pharmaceutical products, the introduction of competitive generic products, the impact of competition from brand-name companies that sell their own generic products or successfully extend the exclusivity period of their branded products, Teva's ability to rapidly integrate the operations of acquired businesses, the availability of product liability coverage in the current insurance market, the impact of pharmaceutical industry regulation and pending legislation that could affect the pharmaceutical industry, the difficulty of predicting U.S. Food and Drug Administration ("FDA") and other regulatory authority approvals, the regulatory environment and changes in the health policies and structure of various countries, acceptance and demand for new pharmaceutical products and new therapies, uncertainties regarding market acceptance of innovative products newly launched, currently being sold or in development, the impact of restructuring of clients, reliance on strategic alliances, exposure to product liability claims, dependence on patent and other protections for innovative products, fluctuations in currency, exchange and interest rates, operating results and other factors that are discussed in Teva's Annual Report on Form 20-F and its other filings with the U.S. Securities and Exchange Commission ("SEC"). Forward-looking statements speak only as of the date on which they are made, and the Company undertakes no obligation to update publicly or revise any forward-looking statement, whether as a result of new information, future developments or otherwise.